Prolotherapy is a nonsurgical, non-opioid treatment that stimulates the body’s natural healing response to repair injured, painful joints, ligaments and tendons. Affected areas are injected with a solution that initiates growth of healthy tissue to reduce pain, improve mobility, and restore function. Prolotherapy has been practiced in the United States since the 1930’s, is supported by a growing body of scientific evidence, and has been endorsed by numerous medical societies and health experts including former U.S. Surgeon General C. Everett Koop. This regenerative medicine therapy is effective in the treatment of chronic pain for musculoskeletal injuries, arthritis, tendinitis, bursitis, and joint instability.